Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2608225..2609813 Replicon chromosome
Accession NZ_LR890493
Organism Klebsiella pneumoniae isolate INF018-sc-2279888

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JMV82_RS12740 Protein ID WP_040148030.1
Coordinates 2608225..2609547 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMV82_RS12745 Protein ID WP_002904790.1
Coordinates 2609547..2609813 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV82_RS12725 2603281..2605782 + 2502 WP_040148028.1 fimbrial biogenesis outer membrane usher protein -
JMV82_RS12730 2605770..2606774 + 1005 WP_040148029.1 type 1 fimbrial protein -
JMV82_RS12735 2606916..2608208 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMV82_RS12740 2608225..2609547 - 1323 WP_040148030.1 type II toxin-antitoxin system HipA family toxin Toxin
JMV82_RS12745 2609547..2609813 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMV82_RS12750 2610078..2610404 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JMV82_RS12755 2610401..2610901 - 501 WP_040148032.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMV82_RS12760 2610879..2612258 - 1380 WP_004184021.1 purine permease -
JMV82_RS12765 2612604..2613758 + 1155 WP_040148035.1 FAD-dependent urate hydroxylase HpxO -
JMV82_RS12770 2613739..2614662 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49155.46 Da        Isoelectric Point: 7.5366

>T291193 WP_040148030.1 NZ_LR890493:c2609547-2608225 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT291193 WP_002904790.1 NZ_LR890493:c2609813-2609547 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References