Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 800388..801045 Replicon chromosome
Accession NZ_LR890493
Organism Klebsiella pneumoniae isolate INF018-sc-2279888

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JMV82_RS03990 Protein ID WP_002916310.1
Coordinates 800635..801045 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JMV82_RS03985 Protein ID WP_002916312.1
Coordinates 800388..800654 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV82_RS03960 795596..797029 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
JMV82_RS03965 797148..797876 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JMV82_RS03970 797926..798237 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
JMV82_RS03975 798401..799060 + 660 WP_002916317.1 hemolysin III family protein -
JMV82_RS03980 799159..800142 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
JMV82_RS03985 800388..800654 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JMV82_RS03990 800635..801045 + 411 WP_002916310.1 protein YgfX Toxin
JMV82_RS03995 801052..801573 - 522 WP_004144730.1 flavodoxin FldB -
JMV82_RS04000 801674..802570 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JMV82_RS04005 802593..803306 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMV82_RS04010 803312..805045 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T291187 WP_002916310.1 NZ_LR890493:800635-801045 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT291187 WP_002916312.1 NZ_LR890493:800388-800654 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References