Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5437735..5438360 Replicon chromosome
Accession NZ_LR890490
Organism Klebsiella pneumoniae isolate INF341-sc-2280155

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JMX00_RS26395 Protein ID WP_040153125.1
Coordinates 5437735..5438118 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag JMX00_RS26400 Protein ID WP_004150355.1
Coordinates 5438118..5438360 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX00_RS26380 5435101..5436003 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
JMX00_RS26385 5436000..5436635 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
JMX00_RS26390 5436632..5437561 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
JMX00_RS26395 5437735..5438118 - 384 WP_040153125.1 type II toxin-antitoxin system VapC family toxin Toxin
JMX00_RS26400 5438118..5438360 - 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
JMX00_RS26405 5438565..5439482 + 918 WP_117079052.1 alpha/beta hydrolase -
JMX00_RS26410 5439496..5440437 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
JMX00_RS26415 5440482..5440919 - 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
JMX00_RS26420 5440916..5441776 - 861 WP_004146232.1 virulence factor BrkB family protein -
JMX00_RS26425 5441770..5442369 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14324.57 Da        Isoelectric Point: 6.7186

>T291183 WP_040153125.1 NZ_LR890490:c5438118-5437735 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQCTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT291183 WP_004150355.1 NZ_LR890490:c5438360-5438118 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References