Detailed information of TA system TA291182

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5111846..5113527
• Replicon: chromosome
• Accession: NZ_LR890490
• Organism: Klebsiella pneumoniae isolate INF341-sc-2280155

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: JMX00_RS24875
• Protein ID: WP_004146663.1
• Coordinates: 5111846..5112763 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: JMX00_RS24880
• Protein ID: WP_101988038.1
• Coordinates: 5112769..5113527 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMX00_RS24855	5107152..5108672	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
JMX00_RS24860	5108669..5109667	+	999	WP_002885172.1	ribose ABC transporter permease	-
JMX00_RS24865	5109698..5110639	+	942	WP_110246479.1	ABC transporter substrate-binding protein	-
JMX00_RS24870	5110714..5111721	+	1008	WP_040152671.1	carbohydrate kinase family protein	-
JMX00_RS24875	5111846..5112763	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JMX00_RS24880	5112769..5113527	-	759	WP_101988038.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
JMX00_RS24885	5113613..5114341	-	729	WP_101988039.1	response regulator transcription factor	-
JMX00_RS24890	5114614..5116761	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
JMX00_RS24895	5117455..5118141	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T291182 WP_004146663.1 NZ_LR890490:c5112763-5111846 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28547.98 Da
• Isoelectric Point: 10.2293

>AT291182 WP_101988038.1 NZ_LR890490:c5113527-5112769 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYKHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: J2XCI1