Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4953401..4953917 Replicon chromosome
Accession NZ_LR890490
Organism Klebsiella pneumoniae isolate INF341-sc-2280155

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag JMX00_RS24065 Protein ID WP_009309309.1
Coordinates 4953401..4953685 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMX00_RS24070 Protein ID WP_002886901.1
Coordinates 4953675..4953917 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX00_RS24040 4948884..4949192 - 309 WP_004178377.1 PTS sugar transporter subunit IIB -
JMX00_RS24045 4949277..4949450 + 174 WP_032408826.1 hypothetical protein -
JMX00_RS24050 4949453..4950196 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JMX00_RS24055 4950553..4952691 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JMX00_RS24060 4952933..4953397 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMX00_RS24065 4953401..4953685 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX00_RS24070 4953675..4953917 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMX00_RS24075 4953995..4955905 - 1911 WP_004152270.1 BglG family transcription antiterminator -
JMX00_RS24080 4955928..4957082 - 1155 WP_032437541.1 lactonase family protein -
JMX00_RS24085 4957149..4957889 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T291181 WP_009309309.1 NZ_LR890490:c4953685-4953401 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT291181 WP_002886901.1 NZ_LR890490:c4953917-4953675 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References