Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2767978..2769566 Replicon chromosome
Accession NZ_LR890490
Organism Klebsiella pneumoniae isolate INF341-sc-2280155

Toxin (Protein)


Gene name hipA Uniprot ID A0A486RAG1
Locus tag JMX00_RS13325 Protein ID WP_016946382.1
Coordinates 2767978..2769300 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMX00_RS13330 Protein ID WP_004176198.1
Coordinates 2769300..2769566 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX00_RS13310 2763034..2765535 + 2502 WP_117078397.1 fimbrial biogenesis outer membrane usher protein -
JMX00_RS13315 2765523..2766527 + 1005 WP_117078398.1 type 1 fimbrial protein -
JMX00_RS13320 2766669..2767961 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMX00_RS13325 2767978..2769300 - 1323 WP_016946382.1 type II toxin-antitoxin system HipA family toxin Toxin
JMX00_RS13330 2769300..2769566 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMX00_RS13335 2769831..2770157 - 327 WP_071443847.1 hydroxyisourate hydrolase -
JMX00_RS13340 2770154..2770654 - 501 WP_085898255.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMX00_RS13345 2770632..2772011 - 1380 WP_021462562.1 purine permease -
JMX00_RS13350 2772357..2773511 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMX00_RS13355 2773492..2774415 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49125.44 Da        Isoelectric Point: 7.5358

>T291178 WP_016946382.1 NZ_LR890490:c2769300-2767978 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT291178 WP_004176198.1 NZ_LR890490:c2769566-2769300 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486RAG1

Antitoxin

Source ID Structure

References