Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2605333..2606921 Replicon chromosome
Accession NZ_LR890484
Organism Klebsiella pneumoniae isolate KSB2_10B-sc-2280350

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JMX01_RS12695 Protein ID WP_040148030.1
Coordinates 2605333..2606655 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMX01_RS12700 Protein ID WP_002904790.1
Coordinates 2606655..2606921 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX01_RS12680 2600389..2602890 + 2502 WP_201506343.1 fimbrial biogenesis outer membrane usher protein -
JMX01_RS12685 2602878..2603882 + 1005 WP_040148029.1 type 1 fimbrial protein -
JMX01_RS12690 2604024..2605316 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMX01_RS12695 2605333..2606655 - 1323 WP_040148030.1 type II toxin-antitoxin system HipA family toxin Toxin
JMX01_RS12700 2606655..2606921 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMX01_RS12705 2607186..2607512 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JMX01_RS12710 2607509..2608009 - 501 WP_040148032.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMX01_RS12715 2607987..2609366 - 1380 WP_099745200.1 purine permease -
JMX01_RS12720 2609712..2610866 + 1155 WP_040148035.1 FAD-dependent urate hydroxylase HpxO -
JMX01_RS12725 2610847..2611770 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49155.46 Da        Isoelectric Point: 7.5366

>T291164 WP_040148030.1 NZ_LR890484:c2606655-2605333 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT291164 WP_002904790.1 NZ_LR890484:c2606921-2606655 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References