Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 262358..263268 Replicon plasmid 2
Accession NZ_LR890475
Organism Klebsiella pneumoniae isolate INF358-sc-2280191

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag JMX23_RS26970 Protein ID WP_004026354.1
Coordinates 262358..262828 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag JMX23_RS26975 Protein ID WP_004026357.1
Coordinates 262825..263268 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX23_RS26955 258891..259895 + 1005 WP_117256483.1 IS110 family transposase -
JMX23_RS26960 260843..261103 + 261 WP_004026352.1 hypothetical protein -
JMX23_RS26965 261715..261903 + 189 WP_024198076.1 hypothetical protein -
JMX23_RS26970 262358..262828 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
JMX23_RS26975 262825..263268 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
JMX23_RS26980 263369..264361 - 993 Protein_259 translesion error-prone DNA polymerase V subunit UmuC -
JMX23_RS26985 264379..265076 - 698 Protein_260 IS1 family transposase -
JMX23_RS26990 265213..265844 + 632 Protein_261 DUF4113 domain-containing protein -
JMX23_RS26995 265923..266151 + 229 Protein_262 type II toxin-antitoxin system Phd/YefM family antitoxin -
JMX23_RS27000 267002..267973 - 972 WP_201525753.1 ParB/RepB/Spo0J family plasmid partition protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS 1..269868 269868
- inside IScluster/Tn - - 254510..264882 10372


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T291155 WP_004026354.1 NZ_LR890475:c262828-262358 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT291155 WP_004026357.1 NZ_LR890475:c263268-262825 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References