Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 255882..256621 Replicon plasmid 2
Accession NZ_LR890475
Organism Klebsiella pneumoniae isolate INF358-sc-2280191

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag JMX23_RS26935 Protein ID WP_021312536.1
Coordinates 255882..256367 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag JMX23_RS26940 Protein ID WP_049095044.1
Coordinates 256355..256621 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX23_RS26910 251504..251800 - 297 WP_094313394.1 hydrogenase expression/formation protein HypD -
JMX23_RS26915 252127..252504 + 378 WP_032719541.1 hypothetical protein -
JMX23_RS26920 252701..253675 - 975 WP_181961417.1 Hok/Gef family protein -
JMX23_RS26925 254277..254438 - 162 WP_004118124.1 type I toxin-antitoxin system Hok family toxin -
JMX23_RS26930 254510..255589 + 1080 WP_117256484.1 IS481-like element ISKpn28 family transposase -
JMX23_RS26935 255882..256367 - 486 WP_021312536.1 GNAT family N-acetyltransferase Toxin
JMX23_RS26940 256355..256621 - 267 WP_049095044.1 DUF1778 domain-containing protein Antitoxin
JMX23_RS26945 256754..257182 - 429 WP_004901287.1 GFA family protein -
JMX23_RS26955 258891..259895 + 1005 WP_117256483.1 IS110 family transposase -
JMX23_RS26960 260843..261103 + 261 WP_004026352.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS 1..269868 269868
- inside IScluster/Tn - - 254510..264882 10372


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17608.39 Da        Isoelectric Point: 10.3370

>T291154 WP_021312536.1 NZ_LR890475:c256367-255882 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10163.63 Da        Isoelectric Point: 4.5256

>AT291154 WP_049095044.1 NZ_LR890475:c256621-256355 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDELAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References