Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 209802..210327 Replicon plasmid 2
Accession NZ_LR890475
Organism Klebsiella pneumoniae isolate INF358-sc-2280191

Toxin (Protein)


Gene name ccdB Uniprot ID J5VBT8
Locus tag JMX23_RS26720 Protein ID WP_004197633.1
Coordinates 210022..210327 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID R4WC25
Locus tag JMX23_RS26715 Protein ID WP_015632547.1
Coordinates 209802..210020 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX23_RS26695 205250..206095 + 846 WP_023345593.1 SDR family oxidoreductase -
JMX23_RS26700 206208..206636 + 429 WP_023345594.1 nuclear transport factor 2 family protein -
JMX23_RS26705 207014..207982 + 969 WP_064167229.1 IS110 family transposase -
JMX23_RS26710 208150..209523 - 1374 WP_048265005.1 hypothetical protein -
JMX23_RS26715 209802..210020 + 219 WP_015632547.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
JMX23_RS26720 210022..210327 + 306 WP_004197633.1 type II toxin-antitoxin system toxin CcdB Toxin
JMX23_RS26725 210514..211502 + 989 Protein_208 hypothetical protein -
JMX23_RS26730 211700..212485 + 786 WP_048291886.1 site-specific integrase -
JMX23_RS26735 212807..213112 - 306 WP_126034233.1 hypothetical protein -
JMX23_RS26740 213261..213638 - 378 WP_158672279.1 DUF1173 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS 1..269868 269868


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11585.27 Da        Isoelectric Point: 6.4661

>T291153 WP_004197633.1 NZ_LR890475:210022-210327 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDDSYRLMTTDMASVTASVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8362.31 Da        Isoelectric Point: 4.7247

>AT291153 WP_015632547.1 NZ_LR890475:209802-210020 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRAERWQAENQEGMAEVARFIDMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MCG5

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1KT86

References