Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 186413..187217 Replicon plasmid 2
Accession NZ_LR890475
Organism Klebsiella pneumoniae isolate INF358-sc-2280191

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag JMX23_RS26600 Protein ID WP_072198182.1
Coordinates 186690..187217 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag JMX23_RS26595 Protein ID WP_048264996.1
Coordinates 186413..186682 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX23_RS26580 181664..182656 + 993 WP_048264993.1 ABC transporter substrate-binding protein -
JMX23_RS26585 182653..183399 + 747 WP_048978068.1 ABC transporter permease -
JMX23_RS26590 183414..185777 + 2364 WP_048264995.1 hypothetical protein -
JMX23_RS26595 186413..186682 + 270 WP_048264996.1 DUF1778 domain-containing protein Antitoxin
JMX23_RS26600 186690..187217 + 528 WP_072198182.1 GNAT family N-acetyltransferase Toxin
JMX23_RS26605 187301..187609 + 309 WP_063444628.1 hypothetical protein -
JMX23_RS26610 187660..188357 + 698 Protein_185 IS1 family transposase -
JMX23_RS26615 188669..189571 - 903 WP_063444656.1 LysR family transcriptional regulator -
JMX23_RS26620 189669..190277 + 609 WP_023345578.1 short chain dehydrogenase -
JMX23_RS26625 190396..191577 - 1182 WP_048977967.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS 1..269868 269868
- flank IS/Tn - - 187854..188357 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(54-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 20078.04 Da        Isoelectric Point: 5.7389

>T291151 WP_072198182.1 NZ_LR890475:186690-187217 [Klebsiella pneumoniae]
VMQELAIEMINDEFDYDIGEFDCGEETLNTFLKDHLKRQHDGQILKGYVLVTKEQKPKLLGYYTLSGSCFERKMLPSKTQ
QRKIPYQNAPSITLGRLAIDKSIQGQGWGELLVTHAMNVVWDASKAVGIYGLFVEALNDKAKRFYTRLDFIQLVGENSNL
LFYPTKSIEKIFTEE

Download         Length: 528 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10148.65 Da        Isoelectric Point: 10.1733

>AT291151 WP_048264996.1 NZ_LR890475:186413-186682 [Klebsiella pneumoniae]
MSALRKQRIDLRLTDDDKSLIEEAAAMSNQTITQFVVASASERAAEVIEQHRRMVLNEESWNLVMDAIANPAAPNERLKR
AAKRLQKMR

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References