Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4569090..4569900 Replicon chromosome
Accession NZ_LR890474
Organism Klebsiella pneumoniae isolate INF358-sc-2280191

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag JMX23_RS22265 Protein ID WP_002887280.1
Coordinates 4569090..4569623 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag JMX23_RS22270 Protein ID WP_002887278.1
Coordinates 4569634..4569900 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX23_RS22260 4567921..4569042 + 1122 WP_012737335.1 cupin domain-containing protein -
JMX23_RS22265 4569090..4569623 - 534 WP_002887280.1 GNAT family N-acetyltransferase Toxin
JMX23_RS22270 4569634..4569900 - 267 WP_002887278.1 DUF1778 domain-containing protein Antitoxin
JMX23_RS22275 4570003..4571436 - 1434 WP_117062898.1 Cu(+)/Ag(+) sensor histidine kinase -
JMX23_RS22280 4571426..4572109 - 684 WP_023313903.1 copper response regulator transcription factor CusR -
JMX23_RS22285 4572282..4573667 + 1386 WP_117062903.1 efflux transporter outer membrane subunit -
JMX23_RS22290 4573685..4574029 + 345 WP_117062899.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T291147 WP_002887280.1 NZ_LR890474:c4569623-4569090 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT291147 WP_002887278.1 NZ_LR890474:c4569900-4569634 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References