Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 812334..812991 Replicon chromosome
Accession NZ_LR890474
Organism Klebsiella pneumoniae isolate INF358-sc-2280191

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JMX23_RS04070 Protein ID WP_002916310.1
Coordinates 812581..812991 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JMX23_RS04065 Protein ID WP_002916312.1
Coordinates 812334..812600 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX23_RS04040 807490..808923 - 1434 WP_065805168.1 6-phospho-beta-glucosidase BglA -
JMX23_RS04045 809042..809770 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JMX23_RS04050 809820..810131 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
JMX23_RS04055 810295..810948 + 654 WP_114264478.1 hemolysin III family protein -
JMX23_RS04060 811105..812088 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
JMX23_RS04065 812334..812600 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JMX23_RS04070 812581..812991 + 411 WP_002916310.1 protein YgfX Toxin
JMX23_RS04075 812998..813519 - 522 WP_004144730.1 flavodoxin FldB -
JMX23_RS04080 813620..814516 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JMX23_RS04085 814539..815252 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMX23_RS04090 815258..816991 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T291140 WP_002916310.1 NZ_LR890474:812581-812991 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT291140 WP_002916312.1 NZ_LR890474:812334-812600 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References