Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 11119..11762 Replicon plasmid 2
Accession NZ_LR890472
Organism Klebsiella pneumoniae isolate INF168-sc-2280023

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag JMX14_RS25955 Protein ID WP_016236302.1
Coordinates 11346..11762 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag JMX14_RS25950 Protein ID WP_001261282.1
Coordinates 11119..11349 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX14_RS25930 6835..7092 - 258 WP_023292103.1 hypothetical protein -
JMX14_RS25935 7696..9150 + 1455 WP_072001611.1 EAL domain-containing protein -
JMX14_RS25940 9768..10199 - 432 WP_174805835.1 hypothetical protein -
JMX14_RS25945 10740..11162 - 423 WP_046624301.1 hypothetical protein -
JMX14_RS25950 11119..11349 + 231 WP_001261282.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JMX14_RS25955 11346..11762 + 417 WP_016236302.1 type II toxin-antitoxin system VapC family toxin Toxin
JMX14_RS25960 11836..13398 + 1563 WP_004206609.1 AAA family ATPase -
JMX14_RS25965 13383..14405 + 1023 WP_032439672.1 helicase UvrD -
JMX14_RS25970 14944..15858 + 915 WP_153378766.1 HNH endonuclease -
JMX14_RS25975 16044..16394 - 351 WP_004187110.1 DUF305 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..177028 177028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15091.55 Da        Isoelectric Point: 7.1084

>T291136 WP_016236302.1 NZ_LR890472:11346-11762 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLELAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT291136 WP_001261282.1 NZ_LR890472:11119-11349 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References