Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4745400..4746103 Replicon chromosome
Accession NZ_LR890471
Organism Klebsiella pneumoniae isolate INF168-sc-2280023

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag JMX14_RS22925 Protein ID WP_017880111.1
Coordinates 4745400..4745741 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag JMX14_RS22930 Protein ID WP_050131139.1
Coordinates 4745762..4746103 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX14_RS22900 4741971..4743098 + 1128 WP_023325431.1 PAAR domain-containing protein -
JMX14_RS22905 4743088..4743351 + 264 WP_004192273.1 hypothetical protein -
JMX14_RS22910 4743497..4743631 + 135 Protein_4495 transposase -
JMX14_RS22915 4743644..4743754 - 111 Protein_4496 DUF4102 domain-containing protein -
JMX14_RS22920 4744129..4745136 - 1008 WP_017880110.1 restriction endonuclease -
JMX14_RS22925 4745400..4745741 - 342 WP_017880111.1 TA system toxin CbtA family protein Toxin
JMX14_RS22930 4745762..4746103 - 342 WP_050131139.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JMX14_RS22935 4746114..4746656 - 543 WP_017880113.1 DNA repair protein RadC -
JMX14_RS22940 4746669..4747112 - 444 WP_017880114.1 antirestriction protein -
JMX14_RS22945 4747143..4747964 - 822 WP_017880115.1 DUF945 domain-containing protein -
JMX14_RS22950 4748085..4748558 - 474 WP_031280324.1 hypothetical protein -
JMX14_RS22955 4748630..4749082 - 453 WP_031280325.1 hypothetical protein -
JMX14_RS22960 4749118..4749834 - 717 WP_032417794.1 WYL domain-containing protein -
JMX14_RS22965 4750078..4750953 - 876 WP_017880120.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4737844..4772610 34766


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-111)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12811.73 Da        Isoelectric Point: 8.4941

>T291133 WP_017880111.1 NZ_LR890471:c4745741-4745400 [Klebsiella pneumoniae]
MKTLPATNPQAATLYLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRAVDIMRARQATGLLKRNRISAAR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12821.45 Da        Isoelectric Point: 6.3148

>AT291133 WP_050131139.1 NZ_LR890471:c4746103-4745762 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNCNMTPCFGARLVQEGNRLHYLADRACITGEFSNAESLKLDEVFTRFIRQMESMLTTGEMNPRH
AHSVTLYHNGFTCEADTLGSCGYVYIAVYPTHR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References