Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4709873..4710683 Replicon chromosome
Accession NZ_LR890471
Organism Klebsiella pneumoniae isolate INF168-sc-2280023

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag JMX14_RS22755 Protein ID WP_004178461.1
Coordinates 4709873..4710406 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag JMX14_RS22760 Protein ID WP_002887278.1
Coordinates 4710417..4710683 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX14_RS22750 4708704..4709825 + 1122 WP_002887282.1 cupin domain-containing protein -
JMX14_RS22755 4709873..4710406 - 534 WP_004178461.1 GNAT family N-acetyltransferase Toxin
JMX14_RS22760 4710417..4710683 - 267 WP_002887278.1 DUF1778 domain-containing protein Antitoxin
JMX14_RS22765 4710786..4712219 - 1434 WP_004894565.1 Cu(+)/Ag(+) sensor histidine kinase -
JMX14_RS22770 4712209..4712892 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
JMX14_RS22775 4713064..4714449 + 1386 WP_004894567.1 efflux transporter outer membrane subunit -
JMX14_RS22780 4714467..4714811 + 345 WP_004894569.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T291132 WP_004178461.1 NZ_LR890471:c4710406-4709873 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT291132 WP_002887278.1 NZ_LR890471:c4710683-4710417 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References