Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3492223..3492835 Replicon chromosome
Accession NZ_LR890466
Organism Escherichia coli isolate MSB1_7A-sc-2280394

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag JMW16_RS16550 Protein ID WP_000833473.1
Coordinates 3492223..3492408 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IWR9
Locus tag JMW16_RS16555 Protein ID WP_000499744.1
Coordinates 3492425..3492835 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW16_RS16540 3489064..3490215 + 1152 WP_000741501.1 L-threonine dehydrogenase -
JMW16_RS16545 3490416..3491954 + 1539 WP_001551836.1 aldehyde dehydrogenase AldB -
JMW16_RS16550 3492223..3492408 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
JMW16_RS16555 3492425..3492835 + 411 WP_000499744.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JMW16_RS16560 3492907..3494871 - 1965 WP_001551835.1 glycoside hydrolase family 127 protein -
JMW16_RS16565 3494882..3496282 - 1401 WP_000204811.1 MFS transporter -
JMW16_RS16570 3496508..3497323 + 816 WP_000891823.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T291104 WP_000833473.1 NZ_LR890466:3492223-3492408 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15241.15 Da        Isoelectric Point: 4.5486

>AT291104 WP_000499744.1 NZ_LR890466:3492425-3492835 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB L4IWR9

References