Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2603492..2604014 Replicon chromosome
Accession NZ_LR890466
Organism Escherichia coli isolate MSB1_7A-sc-2280394

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag JMW16_RS12460 Protein ID WP_001105433.1
Coordinates 2603492..2603782 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag JMW16_RS12465 Protein ID WP_000212715.1
Coordinates 2603772..2604014 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW16_RS12445 2598660..2600315 + 1656 WP_001550509.1 alpha,alpha-phosphotrehalase -
JMW16_RS12450 2600709..2602847 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
JMW16_RS12455 2603027..2603491 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMW16_RS12460 2603492..2603782 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW16_RS12465 2603772..2604014 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMW16_RS12470 2604206..2604592 - 387 WP_001232246.1 cytochrome b562 -
JMW16_RS12475 2604775..2606127 - 1353 WP_001162173.1 metalloprotease PmbA -
JMW16_RS12480 2606221..2606772 + 552 WP_000166270.1 ribosome-associated protein -
JMW16_RS12485 2606922..2608295 - 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T291098 WP_001105433.1 NZ_LR890466:c2603782-2603492 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT291098 WP_000212715.1 NZ_LR890466:c2604014-2603772 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References