Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 105845..106755 Replicon plasmid 2
Accession NZ_LR890465
Organism Klebsiella pneumoniae isolate INF079-sc-2280008

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag JMW83_RS26385 Protein ID WP_004026354.1
Coordinates 105845..106315 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag JMW83_RS26390 Protein ID WP_004026357.1
Coordinates 106312..106755 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW83_RS26365 101727..102329 - 603 WP_011251277.1 hypothetical protein -
JMW83_RS26370 102332..102475 - 144 WP_201514056.1 hypothetical protein -
JMW83_RS26375 102513..103660 + 1148 WP_094283415.1 IS3 family transposase -
JMW83_RS26380 104999..105696 - 698 Protein_109 IS1 family transposase -
JMW83_RS26385 105845..106315 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
JMW83_RS26390 106312..106755 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
JMW83_RS26395 106856..107359 - 504 Protein_112 DUF4113 domain-containing protein -
JMW83_RS26400 107457..107678 - 222 WP_004213643.1 DUF2188 domain-containing protein -
JMW83_RS26405 107823..107978 - 156 WP_004213642.1 hypothetical protein -
JMW83_RS26410 108053..110179 - 2127 WP_004213640.1 TonB-dependent receptor family protein -
JMW83_RS26415 110266..111219 - 954 Protein_116 fec operon regulator FecR -
JMW83_RS26420 111216..111737 - 522 WP_004213635.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 1..233932 233932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T291085 WP_004026354.1 NZ_LR890465:c106315-105845 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT291085 WP_004026357.1 NZ_LR890465:c106755-106312 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References