Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5329157..5329782 Replicon chromosome
Accession NZ_LR890464
Organism Klebsiella pneumoniae isolate INF079-sc-2280008

Toxin (Protein)


Gene name vapC Uniprot ID A0A330XB05
Locus tag JMW83_RS25470 Protein ID WP_012737091.1
Coordinates 5329157..5329540 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag JMW83_RS25475 Protein ID WP_004150355.1
Coordinates 5329540..5329782 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW83_RS25455 5326523..5327425 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
JMW83_RS25460 5327422..5328057 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
JMW83_RS25465 5328054..5328983 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
JMW83_RS25470 5329157..5329540 - 384 WP_012737091.1 type II toxin-antitoxin system VapC family toxin Toxin
JMW83_RS25475 5329540..5329782 - 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
JMW83_RS25480 5329987..5330904 + 918 WP_012737090.1 alpha/beta hydrolase -
JMW83_RS25485 5330918..5331859 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
JMW83_RS25490 5331904..5332341 - 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
JMW83_RS25495 5332338..5333198 - 861 WP_004146232.1 virulence factor BrkB family protein -
JMW83_RS25500 5333192..5333791 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14266.53 Da        Isoelectric Point: 7.2771

>T291083 WP_012737091.1 NZ_LR890464:c5329540-5329157 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRCEAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKGFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT291083 WP_004150355.1 NZ_LR890464:c5329782-5329540 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A330XB05

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References