Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2703738..2705326 Replicon chromosome
Accession NZ_LR890464
Organism Klebsiella pneumoniae isolate INF079-sc-2280008

Toxin (Protein)


Gene name hipA Uniprot ID A0A331XLA5
Locus tag JMW83_RS12955 Protein ID WP_014907613.1
Coordinates 2703738..2705060 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMW83_RS12960 Protein ID WP_002904790.1
Coordinates 2705060..2705326 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW83_RS12940 2698794..2701295 + 2502 WP_014907611.1 fimbrial biogenesis outer membrane usher protein -
JMW83_RS12945 2701283..2702287 + 1005 WP_014907612.1 type 1 fimbrial protein -
JMW83_RS12950 2702429..2703721 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMW83_RS12955 2703738..2705060 - 1323 WP_014907613.1 type II toxin-antitoxin system HipA family toxin Toxin
JMW83_RS12960 2705060..2705326 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMW83_RS12965 2705564..2705890 - 327 WP_004215084.1 hydroxyisourate hydrolase -
JMW83_RS12970 2705887..2706387 - 501 WP_004184022.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMW83_RS12975 2706365..2707744 - 1380 WP_004184021.1 purine permease -
JMW83_RS12980 2708090..2709244 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMW83_RS12985 2709225..2710148 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49139.47 Da        Isoelectric Point: 7.5367

>T291079 WP_014907613.1 NZ_LR890464:c2705060-2703738 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT291079 WP_002904790.1 NZ_LR890464:c2705326-2705060 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331XLA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References