Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 797667..798324 Replicon chromosome
Accession NZ_LR890464
Organism Klebsiella pneumoniae isolate INF079-sc-2280008

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JMW83_RS03955 Protein ID WP_002916310.1
Coordinates 797914..798324 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JMW83_RS03950 Protein ID WP_002916312.1
Coordinates 797667..797933 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW83_RS03925 792875..794308 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
JMW83_RS03930 794427..795155 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JMW83_RS03935 795205..795516 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
JMW83_RS03940 795680..796339 + 660 WP_002916317.1 hemolysin III family protein -
JMW83_RS03945 796438..797421 - 984 WP_014906951.1 tRNA-modifying protein YgfZ -
JMW83_RS03950 797667..797933 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JMW83_RS03955 797914..798324 + 411 WP_002916310.1 protein YgfX Toxin
JMW83_RS03960 798331..798852 - 522 WP_002916308.1 flavodoxin FldB -
JMW83_RS03965 798953..799849 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JMW83_RS03970 799872..800585 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMW83_RS03975 800591..802324 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-132)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T291074 WP_002916310.1 NZ_LR890464:797914-798324 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT291074 WP_002916312.1 NZ_LR890464:797667-797933 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References