Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 80394..81130 Replicon plasmid 3
Accession NZ_LR890459
Organism Klebsiella pneumoniae isolate KSB1_6G-sc-2280276

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag JMX47_RS28110 Protein ID WP_023329018.1
Coordinates 80648..81130 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag JMX47_RS28105 Protein ID WP_003026799.1
Coordinates 80394..80660 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX47_RS28080 75682..76890 + 1209 WP_023329016.1 imidazolonepropionase -
JMX47_RS28085 76883..77692 + 810 WP_023329017.1 N-formylglutamate deformylase -
JMX47_RS28090 77844..77966 - 123 WP_077253309.1 integrase core domain-containing protein -
JMX47_RS28095 78136..79104 + 969 WP_003031967.1 IS110 family transposase -
JMX47_RS28100 79123..79290 - 168 Protein_89 transposase -
JMX47_RS28105 80394..80660 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
JMX47_RS28110 80648..81130 + 483 WP_023329018.1 GNAT family N-acetyltransferase Toxin
JMX47_RS28115 81332..82048 + 717 Protein_92 IS3-like element ISKpn38 family transposase -
JMX47_RS28120 82330..83193 - 864 WP_020803592.1 toll/interleukin-1 receptor domain-containing protein -
JMX47_RS28125 83210..83668 - 459 WP_077252872.1 hypothetical protein -
JMX47_RS28130 84075..85070 + 996 WP_023329021.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..243662 243662
- inside IScluster/Tn - - 78136..82048 3912


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17255.84 Da        Isoelectric Point: 7.8840

>T291071 WP_023329018.1 NZ_LR890459:80648-81130 [Klebsiella pneumoniae]
VGCITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAEGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT291071 WP_003026799.1 NZ_LR890459:80394-80660 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References