Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | stbDE/ParE-YafN |
Location | 62467..62989 | Replicon | plasmid 3 |
Accession | NZ_LR890459 | ||
Organism | Klebsiella pneumoniae isolate KSB1_6G-sc-2280276 |
Toxin (Protein)
Gene name | stbE | Uniprot ID | A0A9J6S4Z8 |
Locus tag | JMX47_RS28010 | Protein ID | WP_004187019.1 |
Coordinates | 62467..62751 (-) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | stbD | Uniprot ID | A0A2J4ZSR4 |
Locus tag | JMX47_RS28015 | Protein ID | WP_004187025.1 |
Coordinates | 62741..62989 (-) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JMX47_RS27995 | 58273..59358 | - | 1086 | WP_201545837.1 | IS481 family transposase | - |
JMX47_RS28000 | 59487..61019 | - | 1533 | WP_009310015.1 | IS3-like element ISKpn38 family transposase | - |
JMX47_RS28005 | 61108..62451 | + | 1344 | WP_023329007.1 | ISNCY family transposase | - |
JMX47_RS28010 | 62467..62751 | - | 285 | WP_004187019.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
JMX47_RS28015 | 62741..62989 | - | 249 | WP_004187025.1 | plasmid stabilization protein | Antitoxin |
JMX47_RS28020 | 63277..64245 | + | 969 | Protein_73 | IS5 family transposase | - |
JMX47_RS28025 | 64350..65717 | - | 1368 | WP_023329010.1 | formimidoylglutamate deiminase | - |
JMX47_RS28030 | 65820..66581 | + | 762 | WP_023329011.1 | histidine utilization repressor | - |
JMX47_RS28035 | 66578..67135 | + | 558 | WP_023329012.1 | HutD family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | pla | 1..243662 | 243662 | |
- | inside | IScluster/Tn | - | - | 58273..64245 | 5972 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11003.72 Da Isoelectric Point: 10.5388
>T291070 WP_004187019.1 NZ_LR890459:c62751-62467 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTLQVQFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGVGK
RENDDIYNATLNRN
MTYKLAFNESALKEWKKLGHTLQVQFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGVGK
RENDDIYNATLNRN
Download Length: 285 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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