Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 62467..62989 Replicon plasmid 3
Accession NZ_LR890459
Organism Klebsiella pneumoniae isolate KSB1_6G-sc-2280276

Toxin (Protein)


Gene name stbE Uniprot ID A0A9J6S4Z8
Locus tag JMX47_RS28010 Protein ID WP_004187019.1
Coordinates 62467..62751 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4ZSR4
Locus tag JMX47_RS28015 Protein ID WP_004187025.1
Coordinates 62741..62989 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX47_RS27995 58273..59358 - 1086 WP_201545837.1 IS481 family transposase -
JMX47_RS28000 59487..61019 - 1533 WP_009310015.1 IS3-like element ISKpn38 family transposase -
JMX47_RS28005 61108..62451 + 1344 WP_023329007.1 ISNCY family transposase -
JMX47_RS28010 62467..62751 - 285 WP_004187019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX47_RS28015 62741..62989 - 249 WP_004187025.1 plasmid stabilization protein Antitoxin
JMX47_RS28020 63277..64245 + 969 Protein_73 IS5 family transposase -
JMX47_RS28025 64350..65717 - 1368 WP_023329010.1 formimidoylglutamate deiminase -
JMX47_RS28030 65820..66581 + 762 WP_023329011.1 histidine utilization repressor -
JMX47_RS28035 66578..67135 + 558 WP_023329012.1 HutD family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..243662 243662
- inside IScluster/Tn - - 58273..64245 5972


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11003.72 Da        Isoelectric Point: 10.5388

>T291070 WP_004187019.1 NZ_LR890459:c62751-62467 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTLQVQFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGVGK
RENDDIYNATLNRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9011.24 Da        Isoelectric Point: 3.9947

>AT291070 WP_004187025.1 NZ_LR890459:c62989-62741 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFHAGDGAPVAILNRNEPAFYCVPPALYAQLMELLEDEELGRMADERSGEKVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZSR4

References