Detailed information of TA system TA291069

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 56323..57233
• Replicon: plasmid 3
• Accession: NZ_LR890459
• Organism: Klebsiella pneumoniae isolate KSB1_6G-sc-2280276

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A2A5MBW7
• Locus tag: JMX47_RS27985
• Protein ID: WP_023329005.1
• Coordinates: 56763..57233 (+)
• Length: 157 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: JMX47_RS27980
• Protein ID: WP_023329004.1
• Coordinates: 56323..56766 (+)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMX47_RS27955	52107..52445	-	339	WP_023328998.1	hypothetical protein	-
JMX47_RS27960	52644..53365	+	722	Protein_61	DUF969 domain-containing protein	-
JMX47_RS27965	53362..54348	+	987	Protein_62	DUF979 domain-containing protein	-
JMX47_RS27970	54358..55353	+	996	WP_023329002.1	DUF2891 domain-containing protein	-
JMX47_RS27975	55514..56201	+	688	Protein_64	DUF4113 domain-containing protein	-
JMX47_RS27980	56323..56766	+	444	WP_023329004.1	DUF2384 domain-containing protein	Antitoxin
JMX47_RS27985	56763..57233	+	471	WP_023329005.1	RES family NAD+ phosphorylase	Toxin
JMX47_RS27990	57344..57603	-	260	Protein_67	hypothetical protein	-
JMX47_RS27995	58273..59358	-	1086	WP_201545837.1	IS481 family transposase	-
JMX47_RS28000	59487..61019	-	1533	WP_009310015.1	IS3-like element ISKpn38 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	pla	1..243662	243662
	-	inside	IScluster/Tn	-	-	58273..64245	5972

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-144)

Sequences

Toxin

Protein

• Length: 157 a.a.
• Molecular weight: 17459.70 Da
• Isoelectric Point: 4.4829

>T291069 WP_023329005.1 NZ_LR890459:56763-57233 [Klebsiella pneumoniae]
VILYRLTKTKNLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPANWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHSDFYGIVQMAQQIPFRFDSRLKPDRK

Nucleotide

• Length: 471 bp

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16477.82 Da
• Isoelectric Point: 10.2498

>AT291069 WP_023329004.1 NZ_LR890459:56323-56766 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADSVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAALKWLNEPNRALSWKVPADLIASETGAYEVIKLITRLEHGVYS

Nucleotide

• Length: 444 bp

Structures

Toxin

• AlphaFold DB: A0A2A5MBW7