Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 56323..57233 Replicon plasmid 3
Accession NZ_LR890459
Organism Klebsiella pneumoniae isolate KSB1_6G-sc-2280276

Toxin (Protein)


Gene name - Uniprot ID A0A2A5MBW7
Locus tag JMX47_RS27985 Protein ID WP_023329005.1
Coordinates 56763..57233 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag JMX47_RS27980 Protein ID WP_023329004.1
Coordinates 56323..56766 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX47_RS27955 52107..52445 - 339 WP_023328998.1 hypothetical protein -
JMX47_RS27960 52644..53365 + 722 Protein_61 DUF969 domain-containing protein -
JMX47_RS27965 53362..54348 + 987 Protein_62 DUF979 domain-containing protein -
JMX47_RS27970 54358..55353 + 996 WP_023329002.1 DUF2891 domain-containing protein -
JMX47_RS27975 55514..56201 + 688 Protein_64 DUF4113 domain-containing protein -
JMX47_RS27980 56323..56766 + 444 WP_023329004.1 DUF2384 domain-containing protein Antitoxin
JMX47_RS27985 56763..57233 + 471 WP_023329005.1 RES family NAD+ phosphorylase Toxin
JMX47_RS27990 57344..57603 - 260 Protein_67 hypothetical protein -
JMX47_RS27995 58273..59358 - 1086 WP_201545837.1 IS481 family transposase -
JMX47_RS28000 59487..61019 - 1533 WP_009310015.1 IS3-like element ISKpn38 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..243662 243662
- inside IScluster/Tn - - 58273..64245 5972


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(94-144)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17459.70 Da        Isoelectric Point: 4.4829

>T291069 WP_023329005.1 NZ_LR890459:56763-57233 [Klebsiella pneumoniae]
VILYRLTKTKNLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPANWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHSDFYGIVQMAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16477.82 Da        Isoelectric Point: 10.2498

>AT291069 WP_023329004.1 NZ_LR890459:56323-56766 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADSVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAALKWLNEPNRALSWKVPADLIASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBW7

Antitoxin

Source ID Structure

References