291068

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 203642..204164 Replicon plasmid 2
Accession NZ_LR890458
Organism Klebsiella pneumoniae isolate KSB1_6G-sc-2280276

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag JMX47_RS27155 Protein ID WP_004181778.1
Coordinates 203880..204164 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag JMX47_RS27150 Protein ID WP_004181777.1
Coordinates 203642..203890 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX47_RS27130 198851..199672 - 822 WP_004181772.1 hypothetical protein -
JMX47_RS27135 199734..200087 - 354 WP_004181774.1 hypothetical protein -
JMX47_RS27140 200232..201218 - 987 WP_025368599.1 hypothetical protein -
JMX47_RS27145 201552..203351 - 1800 WP_004181776.1 ATP-dependent helicase -
JMX47_RS27150 203642..203890 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JMX47_RS27155 203880..204164 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX47_RS27165 205654..206880 + 1227 WP_040209639.1 transposase -
JMX47_RS27170 207151..207375 - 225 Protein_217 transposase -
JMX47_RS27175 207454..207882 - 429 WP_077257669.1 IS200/IS605 family transposase -
JMX47_RS27180 207918..209105 + 1188 WP_040209642.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..311523 311523


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T291068 WP_004181778.1 NZ_LR890458:203880-204164 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT291068 WP_004181777.1 NZ_LR890458:203642-203890 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References