Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 45698..46224 Replicon plasmid 2
Accession NZ_LR890458
Organism Klebsiella pneumoniae isolate KSB1_6G-sc-2280276

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag JMX47_RS26380 Protein ID WP_000323025.1
Coordinates 45937..46224 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag JMX47_RS26375 Protein ID WP_004196370.1
Coordinates 45698..45937 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX47_RS26345 41035..41227 - 193 Protein_52 MFS transporter -
JMX47_RS26350 41257..42234 + 978 WP_004196334.1 chromate resistance protein -
JMX47_RS26355 42191..43567 + 1377 WP_004196363.1 chromate efflux transporter -
JMX47_RS26360 43598..44287 - 690 WP_004196322.1 hypothetical protein -
JMX47_RS26365 44301..45038 - 738 WP_008460272.1 HupE/UreJ family protein -
JMX47_RS26370 45082..45447 - 366 WP_009651956.1 hypothetical protein -
JMX47_RS26375 45698..45937 + 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
JMX47_RS26380 45937..46224 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
JMX47_RS26385 46296..46454 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
JMX47_RS26390 47060..48034 + 975 WP_004196336.1 hypothetical protein -
JMX47_RS26395 48232..48609 - 378 WP_045289277.1 hypothetical protein -
JMX47_RS26400 48936..49232 + 297 WP_094313394.1 hydrogenase expression/formation protein HypD -
JMX47_RS26405 49301..50368 + 1068 WP_049130554.1 hypothetical protein -
JMX47_RS26410 50524..50871 + 348 WP_042935949.1 hypothetical protein -
JMX47_RS26415 50950..51183 + 234 WP_042935952.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..311523 311523


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T291067 WP_000323025.1 NZ_LR890458:45937-46224 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT291067 WP_004196370.1 NZ_LR890458:45698-45937 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References