Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 28741..29651 Replicon plasmid 2
Accession NZ_LR890458
Organism Klebsiella pneumoniae isolate KSB1_6G-sc-2280276

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag JMX47_RS26285 Protein ID WP_049165696.1
Coordinates 29181..29651 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A7H4PRG4
Locus tag JMX47_RS26280 Protein ID WP_032413443.1
Coordinates 28741..29184 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX47_RS26255 24684..25490 - 807 WP_048268727.1 SagB/ThcOx family dehydrogenase -
JMX47_RS26260 25492..26346 - 855 WP_048268726.1 McbB family protein -
JMX47_RS26265 26405..26614 - 210 WP_072072310.1 microcin B17 -
JMX47_RS26270 26865..27323 - 459 Protein_37 recombinase family protein -
JMX47_RS26275 27466..28641 + 1176 Protein_38 translesion error-prone DNA polymerase V subunit UmuC -
JMX47_RS26280 28741..29184 + 444 WP_032413443.1 DUF2384 domain-containing protein Antitoxin
JMX47_RS26285 29181..29651 + 471 WP_049165696.1 RES family NAD+ phosphorylase Toxin
JMX47_RS26290 29761..30021 - 261 WP_004026352.1 hypothetical protein -
JMX47_RS26295 30583..31764 - 1182 WP_004883380.1 IS481 family transposase -
JMX47_RS26300 31893..33425 - 1533 WP_009310015.1 IS3-like element ISKpn38 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..311523 311523
- inside IScluster/Tn - - 26865..33425 6560


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre

(16-147)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17485.70 Da        Isoelectric Point: 4.6155

>T291066 WP_049165696.1 NZ_LR890458:29181-29651 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANTD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16508.82 Da        Isoelectric Point: 10.3013

>AT291066 WP_032413443.1 NZ_LR890458:28741-29184 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7H4PRG4

References