Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4769567..4770083 Replicon chromosome
Accession NZ_LR890457
Organism Klebsiella pneumoniae isolate KSB1_6G-sc-2280276

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag JMX47_RS23410 Protein ID WP_002886902.1
Coordinates 4769567..4769851 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMX47_RS23415 Protein ID WP_002886901.1
Coordinates 4769841..4770083 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX47_RS23385 4765051..4765359 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
JMX47_RS23390 4765444..4765617 + 174 WP_019725541.1 hypothetical protein -
JMX47_RS23395 4765620..4766363 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JMX47_RS23400 4766720..4768858 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JMX47_RS23405 4769099..4769563 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMX47_RS23410 4769567..4769851 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX47_RS23415 4769841..4770083 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMX47_RS23420 4770161..4772071 - 1911 WP_023328821.1 BglG family transcription antiterminator -
JMX47_RS23425 4772094..4773248 - 1155 WP_002886900.1 lactonase family protein -
JMX47_RS23430 4773315..4774055 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T291063 WP_002886902.1 NZ_LR890457:c4769851-4769567 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT291063 WP_002886901.1 NZ_LR890457:c4770083-4769841 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References