Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 837456..837933 Replicon chromosome
Accession NC_020537
Organism Staphylococcus aureus subsp. aureus ST228

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SAI7S6_RS04040 Protein ID WP_000052076.1
Coordinates 837456..837644 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAI7S6_RS04045 Protein ID WP_001059690.1
Coordinates 837673..837933 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAI7S6_RS04010 833450..833971 + 522 WP_000824485.1 hypothetical protein -
SAI7S6_RS04015 834312..834998 + 687 WP_000141557.1 thermonuclease family protein -
SAI7S6_RS04020 835355..835555 + 201 WP_001059082.1 cold-shock protein -
SAI7S6_RS04025 836047..836265 - 219 WP_000005886.1 hypothetical protein -
SAI7S6_RS04030 836327..836611 - 285 WP_001004399.1 hypothetical protein -
SAI7S6_RS04035 836699..837268 - 570 WP_001106654.1 hypothetical protein -
SAI7S6_RS04040 837456..837644 - 189 WP_000052076.1 hypothetical protein Toxin
SAI7S6_RS04045 837673..837933 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAI7S6_RS04050 838274..838477 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAI7S6_RS04055 838474..838710 - 237 WP_000349581.1 hypothetical protein -
SAI7S6_RS04060 838935..839516 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
SAI7S6_RS04065 839589..840206 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
SAI7S6_RS04070 840361..840855 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAI7S6_RS04075 841254..841676 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
SAI7S6_RS04080 841824..842540 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T29106 WP_000052076.1 NC_020537:c837644-837456 [Staphylococcus aureus subsp. aureus ST228]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T29106 NC_020537:c837644-837456 [Staphylococcus aureus subsp. aureus ST228]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT29106 WP_001059690.1 NC_020537:c837933-837673 [Staphylococcus aureus subsp. aureus ST228]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT29106 NC_020537:c837933-837673 [Staphylococcus aureus subsp. aureus ST228]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References