Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4544678..4545194 Replicon chromosome
Accession NZ_LR890456
Organism Klebsiella pneumoniae isolate INF032-sc-2279918

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JMV68_RS22065 Protein ID WP_040170298.1
Coordinates 4544678..4544962 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMV68_RS22070 Protein ID WP_002886901.1
Coordinates 4544952..4545194 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV68_RS22040 4540095..4540403 - 309 WP_004186703.1 PTS sugar transporter subunit IIB -
JMV68_RS22045 4540488..4540661 + 174 WP_004222159.1 hypothetical protein -
JMV68_RS22050 4540664..4541407 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JMV68_RS22055 4541764..4543902 + 2139 WP_064148390.1 anaerobic ribonucleoside-triphosphate reductase -
JMV68_RS22060 4544210..4544674 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMV68_RS22065 4544678..4544962 - 285 WP_040170298.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV68_RS22070 4544952..4545194 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMV68_RS22075 4545272..4547182 - 1911 WP_004152270.1 BglG family transcription antiterminator -
JMV68_RS22080 4547205..4548359 - 1155 WP_064148391.1 lactonase family protein -
JMV68_RS22085 4548426..4549166 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11186.06 Da        Isoelectric Point: 10.3787

>T291048 WP_040170298.1 NZ_LR890456:c4544962-4544678 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGEMVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT291048 WP_002886901.1 NZ_LR890456:c4545194-4544952 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References