Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2526395..2527983 Replicon chromosome
Accession NZ_LR890456
Organism Klebsiella pneumoniae isolate INF032-sc-2279918

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JMV68_RS12420 Protein ID WP_064148190.1
Coordinates 2526395..2527717 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMV68_RS12425 Protein ID WP_040216240.1
Coordinates 2527717..2527983 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV68_RS12405 2521451..2523952 + 2502 WP_004184030.1 fimbrial biogenesis outer membrane usher protein -
JMV68_RS12410 2523940..2524944 + 1005 WP_064148189.1 type 1 fimbrial protein -
JMV68_RS12415 2525086..2526378 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMV68_RS12420 2526395..2527717 - 1323 WP_064148190.1 type II toxin-antitoxin system HipA family toxin Toxin
JMV68_RS12425 2527717..2527983 - 267 WP_040216240.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMV68_RS12430 2528370..2528696 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JMV68_RS12435 2528693..2529193 - 501 WP_032432595.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMV68_RS12440 2529171..2530550 - 1380 WP_004184021.1 purine permease -
JMV68_RS12445 2530896..2532050 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMV68_RS12450 2532031..2532954 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49201.49 Da        Isoelectric Point: 7.5357

>T291045 WP_064148190.1 NZ_LR890456:c2527717-2526395 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDSGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9959.39 Da        Isoelectric Point: 8.6103

>AT291045 WP_040216240.1 NZ_LR890456:c2527983-2527717 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DHNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References