Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1734086..1734676 Replicon chromosome
Accession NZ_LR890456
Organism Klebsiella pneumoniae isolate INF032-sc-2279918

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag JMV68_RS08375 Protein ID WP_021466317.1
Coordinates 1734344..1734676 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A3S7DDD0
Locus tag JMV68_RS08370 Protein ID WP_000288812.1
Coordinates 1734086..1734343 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV68_RS08355 1731429..1732691 - 1263 WP_200549280.1 hypothetical protein -
JMV68_RS08360 1733076..1733548 + 473 Protein_1632 hypothetical protein -
JMV68_RS08365 1733545..1733751 + 207 WP_020805021.1 helix-turn-helix domain-containing protein -
JMV68_RS08370 1734086..1734343 + 258 WP_000288812.1 antitoxin Antitoxin
JMV68_RS08375 1734344..1734676 + 333 WP_021466317.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JMV68_RS08385 1734999..1736435 + 1437 WP_004151469.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
JMV68_RS08395 1736801..1738255 - 1455 WP_004148975.1 AMP nucleosidase -
JMV68_RS08400 1738385..1738630 - 246 WP_004141189.1 signal transduction protein PmrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1724339..1734676 10337


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11899.82 Da        Isoelectric Point: 10.4722

>T291040 WP_021466317.1 NZ_LR890456:1734344-1734676 [Klebsiella pneumoniae]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARKGKRLERIPDAVVNEVLARLDAMLS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9442.92 Da        Isoelectric Point: 4.3566

>AT291040 WP_000288812.1 NZ_LR890456:1734086-1734343 [Klebsiella pneumoniae]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3S7DDD0

References