Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 45121..45881 Replicon plasmid 2
Accession NZ_LR890447
Organism Klebsiella pneumoniae isolate INF171-sc-2280028

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag JMW80_RS26115 Protein ID WP_064177585.1
Coordinates 45375..45881 (+) Length 169 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag JMW80_RS26110 Protein ID WP_003026799.1
Coordinates 45121..45387 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW80_RS26065 40806..40904 - 99 WP_004118688.1 type II toxin-antitoxin system RelE/ParE family toxin -
JMW80_RS26070 40891..41070 - 180 WP_065520248.1 type II toxin-antitoxin system ParD family antitoxin -
JMW80_RS26075 41383..41628 + 246 WP_064177598.1 hypothetical protein -
JMW80_RS26080 41633..42205 + 573 WP_064177597.1 hypothetical protein -
JMW80_RS26085 42236..42730 + 495 WP_064177596.1 hypothetical protein -
JMW80_RS26090 42791..42994 + 204 WP_004213596.1 hemolysin expression modulator Hha -
JMW80_RS26095 43008..43238 + 231 WP_049118762.1 hypothetical protein -
JMW80_RS26105 44691..44945 + 255 WP_044246670.1 hypothetical protein -
JMW80_RS26110 45121..45387 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
JMW80_RS26115 45375..45881 + 507 WP_064177585.1 GNAT family N-acetyltransferase Toxin
JMW80_RS26120 46064..47410 + 1347 WP_077255522.1 ISNCY family transposase -
JMW80_RS26125 47459..47857 + 399 WP_032422684.1 helix-turn-helix domain-containing protein -
JMW80_RS26130 48037..49068 + 1032 WP_074194396.1 IS630-like element ISEc33 family transposase -
JMW80_RS26135 49160..49435 - 276 WP_071717249.1 IS3 family transposase -
JMW80_RS26140 49545..50481 + 937 Protein_49 ISNCY family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..158730 158730
- inside IScluster/Tn - - 38059..50502 12443


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(74-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 18119.99 Da        Isoelectric Point: 9.6090

>T291036 WP_064177585.1 NZ_LR890447:45375-45881 [Klebsiella pneumoniae]
VGCITAPEPLSSAHQLAEFVSGETVLDEWLRQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP
RLIIGVGK

Download         Length: 507 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT291036 WP_003026799.1 NZ_LR890447:45121-45387 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References