Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4794102..4794618 Replicon chromosome
Accession NZ_LR890446
Organism Klebsiella pneumoniae isolate INF171-sc-2280028

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag JMW80_RS23260 Protein ID WP_002886902.1
Coordinates 4794102..4794386 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMW80_RS23265 Protein ID WP_002886901.1
Coordinates 4794376..4794618 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW80_RS23235 4789519..4789827 - 309 WP_004178377.1 PTS sugar transporter subunit IIB -
JMW80_RS23240 4789912..4790085 + 174 WP_032410138.1 hypothetical protein -
JMW80_RS23245 4790088..4790831 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
JMW80_RS23250 4791188..4793326 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JMW80_RS23255 4793634..4794098 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMW80_RS23260 4794102..4794386 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW80_RS23265 4794376..4794618 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMW80_RS23270 4794696..4796606 - 1911 WP_004152270.1 BglG family transcription antiterminator -
JMW80_RS23275 4796629..4797783 - 1155 WP_002886900.1 lactonase family protein -
JMW80_RS23280 4797850..4798590 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T291033 WP_002886902.1 NZ_LR890446:c4794386-4794102 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT291033 WP_002886901.1 NZ_LR890446:c4794618-4794376 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References