Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4705192..4705895 Replicon chromosome
Accession NZ_LR890446
Organism Klebsiella pneumoniae isolate INF171-sc-2280028

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag JMW80_RS22885 Protein ID WP_032728834.1
Coordinates 4705192..4705533 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag JMW80_RS22890 Protein ID WP_062729743.1
Coordinates 4705554..4705895 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW80_RS22870 4700677..4702164 + 1488 WP_021441098.1 hypothetical protein -
JMW80_RS22880 4703926..4704933 - 1008 WP_073511318.1 restriction endonuclease -
JMW80_RS22885 4705192..4705533 - 342 WP_032728834.1 TA system toxin CbtA family protein Toxin
JMW80_RS22890 4705554..4705895 - 342 WP_062729743.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JMW80_RS22895 4705906..4706445 - 540 WP_062729744.1 DNA repair protein RadC -
JMW80_RS22900 4706458..4706901 - 444 WP_049594271.1 antirestriction protein -
JMW80_RS22905 4706932..4707753 - 822 WP_073511317.1 DUF945 domain-containing protein -
JMW80_RS22910 4707826..4708083 - 258 WP_073511316.1 DUF905 domain-containing protein -
JMW80_RS22915 4708155..4708604 - 450 WP_015699704.1 hypothetical protein -
JMW80_RS22920 4708601..4709053 - 453 WP_062933992.1 hypothetical protein -
JMW80_RS22925 4709090..4709659 - 570 WP_073511315.1 hypothetical protein -
JMW80_RS22930 4709659..4710363 - 705 WP_073511314.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4691679..4735808 44129


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12777.71 Da        Isoelectric Point: 7.1648

>T291032 WP_032728834.1 NZ_LR890446:c4705533-4705192 [Klebsiella pneumoniae]
MKTLPATTPQAATLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGITLADAVNFLVEKYELVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAQ

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12747.39 Da        Isoelectric Point: 6.6214

>AT291032 WP_062729743.1 NZ_LR890446:c4705895-4705554 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFSEAECLKLDVAFPHFISQMESMLTTGEMNPRH
AHCFTLYHNGFSCEADTLGSCGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References