291031

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4664735..4665545 Replicon chromosome
Accession NZ_LR890446
Organism Klebsiella pneumoniae isolate INF171-sc-2280028

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag JMW80_RS22700 Protein ID WP_004178461.1
Coordinates 4664735..4665268 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag JMW80_RS22705 Protein ID WP_002887278.1
Coordinates 4665279..4665545 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW80_RS22695 4663566..4664687 + 1122 WP_021441121.1 cupin domain-containing protein -
JMW80_RS22700 4664735..4665268 - 534 WP_004178461.1 GNAT family N-acetyltransferase Toxin
JMW80_RS22705 4665279..4665545 - 267 WP_002887278.1 DUF1778 domain-containing protein Antitoxin
JMW80_RS22710 4665648..4667081 - 1434 WP_021441120.1 Cu(+)/Ag(+) sensor histidine kinase -
JMW80_RS22715 4667071..4667754 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
JMW80_RS22720 4667927..4669312 + 1386 WP_038806759.1 efflux transporter outer membrane subunit -
JMW80_RS22725 4669330..4669674 + 345 WP_021441118.1 cation efflux system protein CusF -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(91-151)

Antitoxin

(2-86)


Sequences


Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T291031 WP_004178461.1 NZ_LR890446:c4665268-4664735 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT291031 WP_002887278.1 NZ_LR890446:c4665545-4665279 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A060VJ83


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLZ1

References