291024

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 854353..855010 Replicon chromosome
Accession NZ_LR890446
Organism Klebsiella pneumoniae isolate INF171-sc-2280028

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JMW80_RS04240 Protein ID WP_002916310.1
Coordinates 854600..855010 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JMW80_RS04235 Protein ID WP_002916312.1
Coordinates 854353..854619 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW80_RS04210 849561..850994 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
JMW80_RS04215 851113..851841 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JMW80_RS04220 851891..852202 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
JMW80_RS04225 852366..853025 + 660 WP_002916317.1 hemolysin III family protein -
JMW80_RS04230 853124..854107 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
JMW80_RS04235 854353..854619 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JMW80_RS04240 854600..855010 + 411 WP_002916310.1 protein YgfX Toxin
JMW80_RS04245 855017..855538 - 522 WP_004144730.1 flavodoxin FldB -
JMW80_RS04250 855639..856535 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JMW80_RS04255 856558..857271 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMW80_RS04260 857277..859010 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T291024 WP_002916310.1 NZ_LR890446:854600-855010 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT291024 WP_002916312.1 NZ_LR890446:854353-854619 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References