291020

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 145688..146424 Replicon plasmid 2
Accession NZ_LR890435
Organism Klebsiella pneumoniae isolate KSB1_9J-sc-2280309

Toxin (Protein)


Gene name tacT Uniprot ID A0A2J5Q928
Locus tag JMX02_RS26950 Protein ID WP_004098919.1
Coordinates 145942..146424 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag JMX02_RS26945 Protein ID WP_032415032.1
Coordinates 145688..145954 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX02_RS26910 140868..141730 + 863 Protein_131 IS3 family transposase -
JMX02_RS26915 142012..143088 + 1077 WP_000227969.1 IS110 family transposase -
JMX02_RS26920 143105..143413 + 309 Protein_133 DDE-type integrase/transposase/recombinase -
JMX02_RS26925 143430..143582 + 153 WP_122985329.1 hypothetical protein -
JMX02_RS26930 143598..143882 - 285 WP_004187019.1 type II toxin-antitoxin system RelE/ParE family toxin -
JMX02_RS26935 143872..144120 - 249 WP_004187025.1 plasmid stabilization protein -
JMX02_RS26940 144374..145342 - 969 WP_000654811.1 IS5 family transposase -
JMX02_RS26945 145688..145954 + 267 WP_032415032.1 DUF1778 domain-containing protein Antitoxin
JMX02_RS26950 145942..146424 + 483 WP_004098919.1 GNAT family N-acetyltransferase Toxin
JMX02_RS26955 146633..147979 + 1347 WP_077254682.1 ISNCY family transposase -
JMX02_RS26960 148038..148832 + 795 WP_004187050.1 tetratricopeptide repeat protein -
JMX02_RS26965 148871..150523 - 1653 WP_032415028.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..212029 212029
- inside IScluster/Tn - - 135353..147979 12626


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17335.06 Da        Isoelectric Point: 10.0704

>T291020 WP_004098919.1 NZ_LR890435:145942-146424 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKKVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10123.53 Da        Isoelectric Point: 4.5141

>AT291020 WP_032415032.1 NZ_LR890435:145688-145954 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDDSAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J5Q928

Antitoxin

Source ID Structure

References