291019

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 143598..144120 Replicon plasmid 2
Accession NZ_LR890435
Organism Klebsiella pneumoniae isolate KSB1_9J-sc-2280309

Toxin (Protein)


Gene name stbE Uniprot ID A0A9J6S4Z8
Locus tag JMX02_RS26930 Protein ID WP_004187019.1
Coordinates 143598..143882 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4ZSR4
Locus tag JMX02_RS26935 Protein ID WP_004187025.1
Coordinates 143872..144120 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX02_RS26900 140103..140450 - 348 WP_004114612.1 IS66 family insertion sequence element accessory protein TnpB -
JMX02_RS26905 140447..140824 - 378 WP_004114613.1 IS66 family insertion sequence hypothetical protein -
JMX02_RS26910 140868..141730 + 863 Protein_131 IS3 family transposase -
JMX02_RS26915 142012..143088 + 1077 WP_000227969.1 IS110 family transposase -
JMX02_RS26920 143105..143413 + 309 Protein_133 DDE-type integrase/transposase/recombinase -
JMX02_RS26925 143430..143582 + 153 WP_122985329.1 hypothetical protein -
JMX02_RS26930 143598..143882 - 285 WP_004187019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX02_RS26935 143872..144120 - 249 WP_004187025.1 plasmid stabilization protein Antitoxin
JMX02_RS26940 144374..145342 - 969 WP_000654811.1 IS5 family transposase -
JMX02_RS26945 145688..145954 + 267 WP_032415032.1 DUF1778 domain-containing protein -
JMX02_RS26950 145942..146424 + 483 WP_004098919.1 GNAT family N-acetyltransferase -
JMX02_RS26955 146633..147979 + 1347 WP_077254682.1 ISNCY family transposase -
JMX02_RS26960 148038..148832 + 795 WP_004187050.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..212029 212029
- inside IScluster/Tn - - 135353..147979 12626


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11003.72 Da        Isoelectric Point: 10.5388

>T291019 WP_004187019.1 NZ_LR890435:c143882-143598 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTLQVQFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGVGK
RENDDIYNATLNRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9011.24 Da        Isoelectric Point: 3.9947

>AT291019 WP_004187025.1 NZ_LR890435:c144120-143872 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFHAGDGAPVAILNRNEPAFYCVPPALYAQLMELLEDEELGRMADERSGEKVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZSR4

References