Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4695406..4696216 Replicon chromosome
Accession NZ_LR890434
Organism Klebsiella pneumoniae isolate KSB1_9J-sc-2280309

Toxin (Protein)


Gene name KacT Uniprot ID A0A332NV98
Locus tag JMX02_RS23155 Protein ID WP_014908042.1
Coordinates 4695406..4695939 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag JMX02_RS23160 Protein ID WP_023343051.1
Coordinates 4695950..4696216 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX02_RS23150 4694237..4695358 + 1122 WP_012737335.1 cupin domain-containing protein -
JMX02_RS23155 4695406..4695939 - 534 WP_014908042.1 GNAT family N-acetyltransferase Toxin
JMX02_RS23160 4695950..4696216 - 267 WP_023343051.1 DUF1778 domain-containing protein Antitoxin
JMX02_RS23165 4696319..4697752 - 1434 WP_023343050.1 Cu(+)/Ag(+) sensor histidine kinase -
JMX02_RS23170 4697742..4698425 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
JMX02_RS23175 4698598..4699983 + 1386 WP_024623207.1 efflux transporter outer membrane subunit -
JMX02_RS23180 4700001..4700345 + 345 WP_004192220.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19795.68 Da        Isoelectric Point: 5.2614

>T291015 WP_014908042.1 NZ_LR890434:c4695939-4695406 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGLGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10021.46 Da        Isoelectric Point: 10.5807

>AT291015 WP_023343051.1 NZ_LR890434:c4696216-4695950 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRRVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332NV98

Antitoxin

Source ID Structure

References