Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4267384..4268090 Replicon chromosome
Accession NZ_LR890434
Organism Klebsiella pneumoniae isolate KSB1_9J-sc-2280309

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag JMX02_RS21145 Protein ID WP_024622903.1
Coordinates 4267722..4268090 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A485WAM6
Locus tag JMX02_RS21140 Protein ID WP_023302278.1
Coordinates 4267384..4267701 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX02_RS21095 4262525..4263349 + 825 WP_023302271.1 DUF945 domain-containing protein -
JMX02_RS21100 4263558..4264268 + 711 WP_023302272.1 DeoR family transcriptional regulator -
JMX02_RS21105 4264294..4264830 + 537 WP_023302273.1 DUF4339 domain-containing protein -
JMX02_RS21110 4264872..4265309 + 438 WP_023301392.1 hypothetical protein -
JMX02_RS21115 4265376..4265786 + 411 WP_023302274.1 hypothetical protein -
JMX02_RS21120 4265864..4266100 + 237 WP_032410024.1 DUF905 domain-containing protein -
JMX02_RS21125 4266187..4266645 + 459 WP_023302275.1 antirestriction protein -
JMX02_RS21130 4266654..4267136 + 483 WP_023302276.1 RadC family protein -
JMX02_RS21135 4267145..4267366 + 222 WP_023302277.1 DUF987 domain-containing protein -
JMX02_RS21140 4267384..4267701 + 318 WP_023302278.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JMX02_RS21145 4267722..4268090 + 369 WP_024622903.1 TA system toxin CbtA family protein Toxin
JMX02_RS21150 4268087..4268428 + 342 WP_024622904.1 hypothetical protein -
JMX02_RS21155 4268551..4271196 - 2646 WP_024622905.1 LuxR family transcriptional regulator -
JMX02_RS21160 4271570..4272529 + 960 WP_023302280.1 thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(4-104)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13651.82 Da        Isoelectric Point: 7.2897

>T291014 WP_024622903.1 NZ_LR890434:4267722-4268090 [Klebsiella pneumoniae]
MKNLPATISQAAKPCLSPVAVWQMLLTHLLEQHYGLMLSDTPFSDEAVIQEHIDAGITLANAVNFLVEKYELVRIDRCGF
SSQVQAPYLTATDILHARKACGLMSRYSYREVSNIVLSRSRI

Download         Length: 369 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11860.67 Da        Isoelectric Point: 6.4629

>AT291014 WP_023302278.1 NZ_LR890434:4267384-4267701 [Klebsiella pneumoniae]
MSNPTWGLLRDITPCLGARLVQEGNRLYYLVDRASITGKFSDAEILKLDVVFPHFISQMESMLTIGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYLTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A485WAM6

References