Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 2640062..2641650 | Replicon | chromosome |
Accession | NZ_LR890434 | ||
Organism | Klebsiella pneumoniae isolate KSB1_9J-sc-2280309 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | A0A486S9S0 |
Locus tag | JMX02_RS12875 | Protein ID | WP_023301940.1 |
Coordinates | 2640062..2641384 (-) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | JMX02_RS12880 | Protein ID | WP_024622638.1 |
Coordinates | 2641384..2641650 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JMX02_RS12860 | 2635118..2637619 | + | 2502 | WP_023301938.1 | fimbrial biogenesis outer membrane usher protein | - |
JMX02_RS12865 | 2637607..2638611 | + | 1005 | WP_023301939.1 | type 1 fimbrial protein | - |
JMX02_RS12870 | 2638753..2640045 | + | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
JMX02_RS12875 | 2640062..2641384 | - | 1323 | WP_023301940.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
JMX02_RS12880 | 2641384..2641650 | - | 267 | WP_024622638.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
JMX02_RS12885 | 2641915..2642241 | - | 327 | WP_004184023.1 | hydroxyisourate hydrolase | - |
JMX02_RS12890 | 2642238..2642738 | - | 501 | WP_004184022.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
JMX02_RS12895 | 2642716..2644095 | - | 1380 | WP_023301941.1 | purine permease | - |
JMX02_RS12900 | 2644441..2645595 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
JMX02_RS12905 | 2645576..2646499 | - | 924 | WP_002904781.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49185.49 Da Isoelectric Point: 7.5358
>T291012 WP_023301940.1 NZ_LR890434:c2641384-2640062 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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