Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2640062..2641650 Replicon chromosome
Accession NZ_LR890434
Organism Klebsiella pneumoniae isolate KSB1_9J-sc-2280309

Toxin (Protein)


Gene name hipA Uniprot ID A0A486S9S0
Locus tag JMX02_RS12875 Protein ID WP_023301940.1
Coordinates 2640062..2641384 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMX02_RS12880 Protein ID WP_024622638.1
Coordinates 2641384..2641650 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX02_RS12860 2635118..2637619 + 2502 WP_023301938.1 fimbrial biogenesis outer membrane usher protein -
JMX02_RS12865 2637607..2638611 + 1005 WP_023301939.1 type 1 fimbrial protein -
JMX02_RS12870 2638753..2640045 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMX02_RS12875 2640062..2641384 - 1323 WP_023301940.1 type II toxin-antitoxin system HipA family toxin Toxin
JMX02_RS12880 2641384..2641650 - 267 WP_024622638.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMX02_RS12885 2641915..2642241 - 327 WP_004184023.1 hydroxyisourate hydrolase -
JMX02_RS12890 2642238..2642738 - 501 WP_004184022.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMX02_RS12895 2642716..2644095 - 1380 WP_023301941.1 purine permease -
JMX02_RS12900 2644441..2645595 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMX02_RS12905 2645576..2646499 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49185.49 Da        Isoelectric Point: 7.5358

>T291012 WP_023301940.1 NZ_LR890434:c2641384-2640062 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9924.30 Da        Isoelectric Point: 8.5912

>AT291012 WP_024622638.1 NZ_LR890434:c2641650-2641384 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYMKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486S9S0

Antitoxin

Source ID Structure

References