Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 90225..91135 Replicon plasmid 2
Accession NZ_LR890425
Organism Klebsiella pneumoniae isolate INF331-sc-2280141

Toxin (Protein)


Gene name - Uniprot ID A0A7D3P3P5
Locus tag JMX49_RS25655 Protein ID WP_023302799.1
Coordinates 90225..90695 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag JMX49_RS25660 Protein ID WP_004026357.1
Coordinates 90692..91135 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX49_RS25635 85752..86150 - 399 WP_004212796.1 H-NS histone family protein -
JMX49_RS25640 86487..86981 - 495 WP_004212794.1 thermonuclease family protein -
JMX49_RS25645 87159..88108 + 950 Protein_85 DUF1173 family protein -
JMX49_RS25650 89494..90191 - 698 Protein_86 IS1 family transposase -
JMX49_RS25655 90225..90695 - 471 WP_023302799.1 RES family NAD+ phosphorylase Toxin
JMX49_RS25660 90692..91135 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
JMX49_RS25665 91236..91739 - 504 Protein_89 DUF4113 domain-containing protein -
JMX49_RS25670 91837..92058 - 222 WP_004213643.1 DUF2188 domain-containing protein -
JMX49_RS25675 92203..92358 - 156 WP_004213642.1 hypothetical protein -
JMX49_RS25680 92433..94559 - 2127 WP_004213640.1 TonB-dependent receptor family protein -
JMX49_RS25685 94646..95599 - 954 Protein_93 fec operon regulator FecR -
JMX49_RS25690 95596..96117 - 522 WP_004213635.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA 1..184695 184695


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-138)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17461.84 Da        Isoelectric Point: 4.4411

>T290984 WP_023302799.1 NZ_LR890425:c90695-90225 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIVWVHHILVMLPTY

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT290984 WP_004026357.1 NZ_LR890425:c91135-90692 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D3P3P5

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References