Detailed information of TA system TA290979

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 4624846..4626183
• Replicon: chromosome
• Accession: NZ_LR890424
• Organism: Klebsiella pneumoniae isolate INF331-sc-2280141

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: JMX49_RS22315
• Protein ID: WP_032424556.1
• Coordinates: 4625248..4626183 (+)
• Length: 312 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: JMX49_RS22310
• Protein ID: WP_023302769.1
• Coordinates: 4624846..4625241 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMX49_RS22280	4620090..4620380	+	291	WP_022615704.1	hypothetical protein	-
JMX49_RS22285	4620445..4621350	+	906	WP_022615703.1	DUF1738 domain-containing protein	-
JMX49_RS22290	4621543..4621914	+	372	WP_022615702.1	hypothetical protein	-
JMX49_RS22295	4622088..4623683	+	1596	WP_023302771.1	TraI domain-containing protein	-
JMX49_RS22300	4623855..4624319	+	465	WP_022615700.1	GNAT family N-acetyltransferase	-
JMX49_RS22305	4624325..4624591	-	267	WP_023302770.1	hypothetical protein	-
JMX49_RS22310	4624846..4625241	+	396	WP_023302769.1	hypothetical protein	Antitoxin
JMX49_RS22315	4625248..4626183	+	936	WP_032424556.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JMX49_RS22320	4626191..4626880	-	690	WP_023302767.1	hypothetical protein	-
JMX49_RS22325	4627080..4627874	-	795	WP_023302766.1	RES domain-containing protein	-
JMX49_RS22330	4628293..4629972	-	1680	WP_201720664.1	tyrosine-type recombinase/integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (34-298)

Antitoxin

• Protein of unknown function DUF6088 (7-109)

Sequences

Toxin

Protein

• Length: 312 a.a.
• Molecular weight: 35389.66 Da
• Isoelectric Point: 5.6165

>T290979 WP_032424556.1 NZ_LR890424:4625248-4626183 [Klebsiella pneumoniae]
MLFSDVTDALGIESGAIVEKDHYIVELLHLLKPLTFDTHQLLFAGGTALAKSGIVLNRMSEDVDIKLVPTDTFLSLSRTQ
RKGIRKEIVQTISHAITATDMFSFDDAHPKVTRDEYRYNDIPVRYPQRVAQAPCLRPFIQLELMEANLLEAPEFRDIHTL
VTTLTGKAPVISAFPCATIISTQAEKLVAMLRRTAAVARNIERQDDASLVRHIYDTYCIVQAGNVDMCLLTDFFKQTIEQ
DIQRYGNQYPQFCVSPNDELKMGLDELEHNPLYKTRYQQFVAPMVYGARKVSWDEAYASFRQMALIILDTY

Nucleotide

• Length: 936 bp

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14800.08 Da
• Isoelectric Point: 11.1078

>AT290979 WP_023302769.1 NZ_LR890424:4624846-4625241 [Klebsiella pneumoniae]
MTIKTRIQSRLKRSKRYVFTRDDFKDIAGYDQIGRVLRDLLKEGQLLKVGYGVYTKARRNSITGKVMPAAPRGSSAVIVE
TLERLKVRYRYEGATQTYNSGESTQIPVSPEIKTSPRFKRALSVGNSKLNG

Nucleotide

• Length: 396 bp