290977

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3962833..3963452 Replicon chromosome
Accession NZ_LR890424
Organism Klebsiella pneumoniae isolate INF331-sc-2280141

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JMX49_RS19165 Protein ID WP_002892050.1
Coordinates 3963234..3963452 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JMX49_RS19160 Protein ID WP_002892066.1
Coordinates 3962833..3963207 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX49_RS19150 3957985..3959178 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JMX49_RS19155 3959201..3962347 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
JMX49_RS19160 3962833..3963207 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JMX49_RS19165 3963234..3963452 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
JMX49_RS19170 3963611..3964177 + 567 WP_002892030.1 maltose O-acetyltransferase -
JMX49_RS19175 3964149..3964289 - 141 WP_004147370.1 hypothetical protein -
JMX49_RS19180 3964310..3964780 + 471 WP_002892026.1 YlaC family protein -
JMX49_RS19185 3964755..3966206 - 1452 WP_004213726.1 PLP-dependent aminotransferase family protein -
JMX49_RS19190 3966307..3967005 + 699 WP_004177238.1 GNAT family N-acetyltransferase -
JMX49_RS19195 3967002..3967142 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JMX49_RS19200 3967142..3967405 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3967465..3968511 1046


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T290977 WP_002892050.1 NZ_LR890424:3963234-3963452 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT290977 WP_002892066.1 NZ_LR890424:3962833-3963207 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References