Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2652143..2653731 Replicon chromosome
Accession NZ_LR890424
Organism Klebsiella pneumoniae isolate INF331-sc-2280141

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JMX49_RS12875 Protein ID WP_004213069.1
Coordinates 2652143..2653465 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMX49_RS12880 Protein ID WP_004176198.1
Coordinates 2653465..2653731 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX49_RS12860 2647199..2649700 + 2502 WP_004213067.1 fimbrial biogenesis outer membrane usher protein -
JMX49_RS12865 2649688..2650692 + 1005 WP_004213068.1 type 1 fimbrial protein -
JMX49_RS12870 2650834..2652126 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMX49_RS12875 2652143..2653465 - 1323 WP_004213069.1 type II toxin-antitoxin system HipA family toxin Toxin
JMX49_RS12880 2653465..2653731 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMX49_RS12885 2654117..2654443 - 327 WP_004215084.1 hydroxyisourate hydrolase -
JMX49_RS12890 2654440..2654940 - 501 WP_004215086.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMX49_RS12895 2654918..2656297 - 1380 WP_004215088.1 purine permease -
JMX49_RS12900 2656643..2657797 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMX49_RS12905 2657778..2658701 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.5357

>T290976 WP_004213069.1 NZ_LR890424:c2653465-2652143 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQATGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT290976 WP_004176198.1 NZ_LR890424:c2653731-2653465 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References