Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 2652143..2653731 | Replicon | chromosome |
Accession | NZ_LR890424 | ||
Organism | Klebsiella pneumoniae isolate INF331-sc-2280141 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | - |
Locus tag | JMX49_RS12875 | Protein ID | WP_004213069.1 |
Coordinates | 2652143..2653465 (-) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | JMX49_RS12880 | Protein ID | WP_004176198.1 |
Coordinates | 2653465..2653731 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JMX49_RS12860 | 2647199..2649700 | + | 2502 | WP_004213067.1 | fimbrial biogenesis outer membrane usher protein | - |
JMX49_RS12865 | 2649688..2650692 | + | 1005 | WP_004213068.1 | type 1 fimbrial protein | - |
JMX49_RS12870 | 2650834..2652126 | + | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
JMX49_RS12875 | 2652143..2653465 | - | 1323 | WP_004213069.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
JMX49_RS12880 | 2653465..2653731 | - | 267 | WP_004176198.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
JMX49_RS12885 | 2654117..2654443 | - | 327 | WP_004215084.1 | hydroxyisourate hydrolase | - |
JMX49_RS12890 | 2654440..2654940 | - | 501 | WP_004215086.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
JMX49_RS12895 | 2654918..2656297 | - | 1380 | WP_004215088.1 | purine permease | - |
JMX49_RS12900 | 2656643..2657797 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
JMX49_RS12905 | 2657778..2658701 | - | 924 | WP_002904781.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49128.44 Da Isoelectric Point: 7.5357
>T290976 WP_004213069.1 NZ_LR890424:c2653465-2652143 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQATGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQATGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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