Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 738018..738775 Replicon chromosome
Accession NZ_LR890415
Organism Klebsiella pneumoniae isolate INF313-sc-2280106

Toxin (Protein)


Gene name tacT Uniprot ID A0A1D8JMF4
Locus tag JMX61_RS03655 Protein ID WP_044159004.1
Coordinates 738293..738775 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A1D8JMH3
Locus tag JMX61_RS03650 Protein ID WP_007372584.1
Coordinates 738018..738302 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX61_RS03630 733410..734132 + 723 WP_013095151.1 TIGR03761 family integrating conjugative element protein -
JMX61_RS03635 734150..736162 + 2013 WP_044159002.1 DNA topoisomerase III -
JMX61_RS03640 736795..737286 + 492 WP_007372582.1 DUF3577 domain-containing protein -
JMX61_RS03645 737362..737862 + 501 WP_007372583.1 single-stranded DNA-binding protein -
JMX61_RS03650 738018..738302 + 285 WP_007372584.1 DUF1778 domain-containing protein Antitoxin
JMX61_RS03655 738293..738775 + 483 WP_044159004.1 GNAT family N-acetyltransferase Toxin
JMX61_RS03660 739008..740294 + 1287 WP_013095156.1 TcpQ domain-containing protein -
JMX61_RS03665 740296..740739 + 444 WP_007372587.1 type IV pilus biogenesis protein PilM -
JMX61_RS03670 740759..742432 + 1674 WP_013095157.1 PilN family type IVB pilus formation outer membrane protein -
JMX61_RS03675 742435..743715 + 1281 WP_176682058.1 type 4b pilus protein PilO2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 725888..833324 107436


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(39-146)

Antitoxin

Vibrio phage ICP1, Orf50

(1-93)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17693.32 Da        Isoelectric Point: 6.9570

>T290940 WP_044159004.1 NZ_LR890415:738293-738775 [Klebsiella pneumoniae]
MEINVTAPALLTEEHVLHSFDCGNAVLDDWLRRRALKNQHLNASRTFVICPEGTACVVGYYSLATGSVSHVDLSRSLRQN
MPDPVPVVLLGRLAVDVSTQGNNFGKWLLNDAVMRVSNLADQVGIKAIMVHAIDERAKAFYEYFGFVQSPVAANTLFYKI

Download         Length: 483 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11078.63 Da        Isoelectric Point: 8.5684

>AT290940 WP_007372584.1 NZ_LR890415:738018-738302 [Klebsiella pneumoniae]
MQTPVRKSVRDKQINIRATDEERAVIDYAASLVNKNRTDFIIERAVHEAQNIILDQRVFVLDDARYQAFIRQLEAPVQNV
EGRQRLMDVKPEWK

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D8JMF4

Antitoxin

Source ID Structure
AlphaFold DB A0A1D8JMH3

References