Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 3597562..3598112 | Replicon | chromosome |
Accession | NZ_LR890410 | ||
Organism | Escherichia coli isolate MSB2_1A-sc-2280429 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | S1PDG4 |
Locus tag | JMW04_RS17090 | Protein ID | WP_001160966.1 |
Coordinates | 3597798..3598112 (+) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | S1NMQ0 |
Locus tag | JMW04_RS17085 | Protein ID | WP_000125568.1 |
Coordinates | 3597562..3597795 (+) | Length | 78 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JMW04_RS17060 | 3592635..3592922 | + | 288 | WP_000203741.1 | ferredoxin-like protein FixX | - |
JMW04_RS17065 | 3592981..3594312 | + | 1332 | WP_001183207.1 | MFS transporter | - |
JMW04_RS17070 | 3594420..3594950 | + | 531 | WP_000600732.1 | glutathione-regulated potassium-efflux system oxidoreductase KefF | - |
JMW04_RS17075 | 3594943..3596805 | + | 1863 | WP_000377109.1 | glutathione-regulated potassium-efflux system protein KefC | - |
JMW04_RS17080 | 3596997..3597476 | + | 480 | WP_000624375.1 | type 3 dihydrofolate reductase | - |
JMW04_RS17085 | 3597562..3597795 | + | 234 | WP_000125568.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
JMW04_RS17090 | 3597798..3598112 | + | 315 | WP_001160966.1 | CcdB family protein | Toxin |
JMW04_RS17095 | 3598109..3598957 | - | 849 | WP_000257181.1 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH | - |
JMW04_RS17100 | 3598964..3599341 | - | 378 | WP_000610901.1 | Co2+/Mg2+ efflux protein ApaG | - |
JMW04_RS17105 | 3599344..3600165 | - | 822 | WP_001065363.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
JMW04_RS17110 | 3600162..3601151 | - | 990 | WP_000241225.1 | 4-hydroxythreonine-4-phosphate dehydrogenase PdxA | - |
JMW04_RS17115 | 3601151..3602437 | - | 1287 | WP_000800457.1 | peptidylprolyl isomerase SurA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11711.72 Da Isoelectric Point: 9.0851
>T290930 WP_001160966.1 NZ_LR890410:3597798-3598112 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
Download Length: 315 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829G815 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829GEF2 |