Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3766472..3767090 Replicon chromosome
Accession NZ_LR890405
Organism Escherichia coli isolate MSB1_7C-sc-2280317

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JMW09_RS18165 Protein ID WP_001291435.1
Coordinates 3766872..3767090 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag JMW09_RS18160 Protein ID WP_000344800.1
Coordinates 3766472..3766846 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW09_RS18150 3761561..3762754 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JMW09_RS18155 3762777..3765926 + 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
JMW09_RS18160 3766472..3766846 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
JMW09_RS18165 3766872..3767090 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
JMW09_RS18170 3767262..3767813 + 552 WP_000102559.1 maltose O-acetyltransferase -
JMW09_RS18175 3767929..3768399 + 471 WP_000136192.1 YlaC family protein -
JMW09_RS18180 3768563..3770113 + 1551 WP_001389864.1 cyclic-guanylate-specific phosphodiesterase PdeB -
JMW09_RS18185 3770155..3770508 - 354 WP_000878140.1 DUF1428 domain-containing protein -
JMW09_RS18195 3770887..3771198 + 312 WP_000409911.1 MGMT family protein -
JMW09_RS18200 3771229..3771801 - 573 WP_000779826.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T290897 WP_001291435.1 NZ_LR890405:3766872-3767090 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT290897 WP_000344800.1 NZ_LR890405:3766472-3766846 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References